The "corporatization" of science     

Hart DM 《Science (New York, N.Y.)》2002,295(5554):439

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Particle track identification: application of a new technique to apollo helmets     

Fleischer RL  Hart HR  Giard WR 《Science (New York, N.Y.)》1970,170(3963):1189-1191

The Apollo helmets are being used to record the dose of heavy particles to which astronauts are exposed on space missions. An improved method for examining and identifying the etched tracks of heavy charged particles consists of replicating tracks and measuring the etching rate as a function of position along the track. Tracks have been observed in Apollo helmets that correspond to ionized atoms heavier than iron.  相似文献   

Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc     

Wells L  Vosseller K  Hart GW 《Science (New York, N.Y.)》2001,291(5512):2376-2378

The dynamic glycosylation of serine or threonine residues on nuclear and cytosolic proteins by O-linked beta-N-acetylglucosamine (O-GlcNAc) is abundant in all multicellular eukaryotes. On several proteins, O-GlcNAc and O-phosphate alternatively occupy the same or adjacent sites, leading to the hypothesis that one function of this saccharide is to transiently block phosphorylation. The diversity of proteins modified by O-GlcNAc implies its importance in many basic cellular and disease processes. Here we systematically examine the current data implicating O-GlcNAc as a regulatory modification important to signal transduction cascades.  相似文献   

Support for Congolese conservationists     

Plumptre A  Hart T  Vedder A  Robinson J 《Science (New York, N.Y.)》2000,288(5466):617

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Recognition of a hidden mineral deposit by an artificial intelligence program     

Campbell AN  Hollister VF  Duda RO  Hart PE 《Science (New York, N.Y.)》1982,217(4563):927-929

A computer program that uses artificial intelligence techniques has successfully identified the location of a porphyry molybdenum deposit. Given geological maps of readily available predrilling exploration data for Mount Tolman in Washington State and using rules obtained from a porphyry molybdenum exploration specialist, the program (called PROSPECTOR) identified the location of previously unknown ore-grade mineralization. This appears to be the first reported determination of the location of mineralization by such a computer-based approach.  相似文献   

Ecology. Synthesizing U.S. river restoration efforts     

Bernhardt ES  Palmer MA  Allan JD  Alexander G  Barnas K  Brooks S  Carr J  Clayton S  Dahm C  Follstad-Shah J  Galat D  Gloss S  Goodwin P  Hart D  Hassett B  Jenkinson R  Katz S  Kondolf GM  Lake PS  Lave R  Meyer JL  O'donnell TK  Pagano L  Powell B  Sudduth E 《Science (New York, N.Y.)》2005,308(5722):636-637

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Response     

Hart SR  Hauri EH  Oschmann LA  Whitehead JA 《Science (New York, N.Y.)》1992,258(5083):821-822

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GROWTH STIMULATING PROPERTIES OF GRASS JUICE     

Kohler GO  Elvehjem CA  Hart EB 《Science (New York, N.Y.)》1936,83(2158):445-446

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Human chromosome 12 is required for elevated HIV-1 expression in human-hamster hybrid cells   总被引：24，自引：0，他引：24  

C E Hart  C Y Ou  J C Galphin  J Moore  L T Bacheler  J J Wasmuth  S R Petteway  G Schochetman 《Science (New York, N.Y.)》1989,246(4929):488-491

Host cell factors act together with regulatory genes of the human immunodeficiency virus (HIV) to control virus production. Human-Chinese hamster ovary hybrid cell clones were used to probe for human chromosomes involved in regulating HIV gene expression. DNA transfection experiments showed that 4 of 18 clones had high levels of HIV gene expression measured by both extracellular virus production and transactivation of the HIV long terminal repeat in the presence of the trans-activator (tat) gene. Karyotype analyses revealed a 94% concordance (17/18) between human chromosome 12 and HIV gene expression. Other chromosomes had an 11 to 72% concordance with virus production.  相似文献   

Deposits of amyloid beta protein in the central nervous system of transgenic mice.   总被引：10，自引：0，他引：10  

D O Wirak  R Bayney  T V Ramabhadran  R P Fracasso  J T Hart  P E Hauer  P Hsiau  S K Pekar  G A Scangos  B D Trapp 《Science (New York, N.Y.)》1991,253(5017):323-325

Alzheimer's disease is characterized by widespread deposition of amyloid in the central nervous system. The 4-kilodalton amyloid beta protein is derived from a larger amyloid precursor protein and forms amyloid deposits in the brain by an unknown pathological mechanism. Except for aged nonhuman primates, there is no animal model for Alzheimer's disease. Transgenic mice expressing amyloid beta protein in the brain could provide such a model. To investigate this possibility, the 4-kilodalton human amyloid beta protein was expressed under the control of the promoter of the human amyloid precursor protein in two lines of transgenic mice. Amyloid beta protein accumulated in the dendrites of some but not all hippocampal neurons in 1-year-old transgenic mice. Aggregates of the amyloid beta protein formed amyloid-like fibrils that are similar in appearance to those in the brains of patients with Alzheimer's disease.  相似文献